Evolution and chronic kidney disease

In "Cardiorenal Syndrome: An Evolutionary Point of View", Ito makes a number of very interesting observations about the evolutionary history of the mammalian kidney, and potential implications this might have for our organs' ability to cope with high salt intake, obesity, and a sedentary lifestyle. A teleological perspective of the renal architecture is also introduced, and serves to illustrate hypotheses concerning the localisation of vascular damage ("strain vessels") and ischemic injuries. Finally, the article is exceptionally concise and clear, without sacrificing detail for brevity.