Renal Physiology

Mathematical modelling of renal physiology, working towards steady-state and transient models of whole-organ function (e.g., water and sodium excretion) as regulated by neurohormonal feedback under physiological and pathological states, and in response to pharmacological interventions. See these interactive plots that compare model excretion rates against data from studies of acute pressure natriuresis in the rat.

There are many potential applications, from teaching medical students to assisting doctors with diagnoses and delivering personalised health-care. This is of particular interest due to the ever-increasing burden of kidney-related diseases such as essential hypertension and diabetes. See my research statement for more details.